QM-FN-SO3
Tocris Bioscience, part of Bio-Techne | Catalog # 7958
Blood-brain barrier penetrant, NIR aggregation-induced emission active probe of amyloid β plaques. Used for: in vitro, in situ and in vivo imaging of amyloid β plaques. Application: confocal microscopy and in vivo imaging
Discontinued Product
7958 has been discontinued.
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Key Product Details
Description
Blood-brain barrier penetrant, NIR aggregation-induced emission active probe of amyloid β plaques. Used for: in vitro, in situ and in vivo imaging of amyloid β plaques. Application: confocal microscopy and in vivo imaging
Product Description
Key information: QM-FN-SO3 is a near-infrared (NIR) aggregation-induced emission active probe for in vivo imaging of amyloid β (Aβ) plaques. Blood brain barrier penetrant.Used for: detection of Aβ plaques in vitro, in situ and in vivo.
Application: confocal microscopy and in vivo imaging.
Properties and Photophysical Data: QM-FN-SO3 shows high binding affinity, ultra-high sensitivity, low signal-to-noise ratio, and large stokes shift (170 nm) reducing excitation light-induced self-quenching. Excitation and emission maxima (λ) are 488 nm and 680 nm, respectively.
Optical Data
| λabs | 488 nm |
| λem | 680 nm |
| Cell Permeable | Yes |
| Application | Confocal imaging of amyloid-beta plaques, in vitro and in vivo |
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Product Specifications
Molecular Weight
564.65
Formula
C29H25N4O3S2.Na
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
Sodium 3-(4-(Dicyanomethylene)-2-(2-(5-(4-(dimethylamino)phenyl)thiophen-2-yl)vinyl)quinolin-1(4H)-yl)propane-1-sulfonate
CAS Number
2316820-94-5
PubChem ID
154727758
InChI Key
WYMGXQAGHDNQOV-UEIGIMKUSA-M
SMILES
CN(C)C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C(N(CCCS(=O)([O-])=O)C3=C/4C=CC=C3)=CC4=C(C#N)/C#N.[Na+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.29 | 20 | |
| DMSO | 28.23 | 50 |
Preparing Stock Solutions
for QM-FN-SO3
The following data is based on the product molecular weight 564.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 2.5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Background References
References are publications that support the biological activity of the product.
- Fu Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J.Am.Chem.Soc. 2019 PMID: 30632737
- Su Strategic design of amyloid-β species fluorescent probes for Alzheimer's disease. ACS Chem.Neurosci. 2022 PMID: 35132849
- Yan Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat.Protoc. 2023 PMID: 36697872
Product Specific Notices for QM-FN-SO3
For research use only
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