Mouse Osteoprotegerin (AAH49782.1) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC3091

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Key Product Details

Species

Mouse

Accession Number

AAH49782.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Osteoprotegerin/TNFRSF11B

Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.

Alternate Names

OCIF, TNFRSF11B

Entrez Gene IDs

4982 (Human); 18383 (Mouse)

Gene Symbol

TNFRSF11B

UniProt

AAH49782.1

Additional Osteoprotegerin/TNFRSF11B Products

Product Documents for Mouse Osteoprotegerin (AAH49782.1) VersaClone cDNA

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Product Specific Notices for Mouse Osteoprotegerin (AAH49782.1) VersaClone cDNA

For research use only

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