Human Wnt-3 (NP_110380.1) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC3679

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Key Product Details

Species

Human

Accession Number

NP_110380.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Wnt-3

Wnt-3a is a secreted protein that is necessary for proper embryonic development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation. It also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells. The post-translational glycosylation and acylation of Wnts are essential for their efficient secretion and biological activity, respectively. Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta-catenin levels. As intracellular beta-catenin levels rise, beta-catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes.

Long Name

Wingless-type MMTV Integration Site Family, Member 3

Alternate Names

INT4, TETAMS, WNT3

Entrez Gene IDs

7473 (Human); 22415 (Mouse)

Gene Symbol

WNT3

UniProt

NP_110380.1 (Human)

Additional Wnt-3 Products

Product Documents for Human Wnt-3 (NP_110380.1) VersaClone cDNA

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human Wnt-3 (NP_110380.1) VersaClone cDNA

For research use only

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