Human VPS34/PIK3C3 (NP_002638) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC2564

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Key Product Details

Species

Human

Accession Number

NP_002638

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: VPS34/PIK3C3

VPS34, also known as phosphoinositide-3-kinase p100 subunit or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. VPS34 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. It exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. The activity of VPS34 is enhanced by manganese and can be regulated by nutrients, suggesting an important role of VPS34 in the regulation of mTOR protein synthesis. VPS34 also forms a complex with Beclin1 that promotes autophagy and tumor supression.

Alternate Names

PI 3-Kinase C3, PI3K type 3, PIK3C3

Entrez Gene IDs

5289 (Human); 225326 (Mouse); 65052 (Rat)

Gene Symbol

PIK3C3

UniProt

NP_002638

Additional VPS34/PIK3C3 Products

Product Documents for Human VPS34/PIK3C3 (NP_002638) VersaClone cDNA

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human VPS34/PIK3C3 (NP_002638) VersaClone cDNA

For research use only

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