Human Patched 2/PTCH2 (NP_003729) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1059
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Patched 2/PTCH2
Patched 2 (Ptch2) is a 180 - 200 kDa 12 transmembrane member of the Patched family. Human PTCH2 is 1203 amino acids (aa) in length. It has two terminal cytoplasmic domains, one between aa 1 - 57, and a second between aa 1115 - 1203. Together with Smoothened (SMO), Ptch2 forms a membrane complex that serves as a receptor for Sonic Hedgehog (SHH).
Human Ptch2 likely has two isoforms. One shows an eight aa extension of the C-terminus, while a second shows a four aa substitution for the C-terminal 61 amino acids (aa 1143 - 1203). Over the first extracellular loop human Patched 2 shares 95% and 96% aa sequence identity with mouse and canine Patched 2, respectively.
Alternate Names
ptc2, PTCH2
Gene Symbol
PTCH2
UniProt
Additional Patched 2/PTCH2 Products
Product Documents for Human Patched 2/PTCH2 (NP_003729) VersaClone cDNA
Product Specific Notices for Human Patched 2/PTCH2 (NP_003729) VersaClone cDNA
For research use only
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