Human MDM2/HDM2 (AAM78554) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC2746
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: MDM2/HDM2
MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.
Long Name
Double Minute 2 Protein
Alternate Names
HDM2
Gene Symbol
MDM2
UniProt
Additional MDM2/HDM2 Products
Product Documents for Human MDM2/HDM2 (AAM78554) VersaClone cDNA
Product Specific Notices for Human MDM2/HDM2 (AAM78554) VersaClone cDNA
For research use only
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