Human ALK/CD246 (NP_004295) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1376
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: ALK/CD246
Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Long Name
Anaplastic Lymphoma Kinase
Alternate Names
CD246, Ki-1, Tcrz
Gene Symbol
ALK
UniProt
Additional ALK/CD246 Products
Product Documents for Human ALK/CD246 (NP_004295) VersaClone cDNA
Product Specific Notices for Human ALK/CD246 (NP_004295) VersaClone cDNA
For research use only
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