SOCS-2 Antibody (6D3F6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16781

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16781-100ul
NBP3-16781-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 6D3F6 expressed in HEK293

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SOCS-2 Antibodies »

Product Specifications

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SOCS-2 (NP_001257400.1). MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit SOCS-2 Antibody (6D3F6) (NBP3-16781) is a recombinant monoclonal antibody validated for use in IHC, WB and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for SOCS-2 Antibody (6D3F6)

Western Blot: SOCS-2 Antibody (6D3F6) [NBP3-16781]

Western Blot: SOCS-2 Antibody (6D3F6) [NBP3-16781]

Western Blot: SOCS-2 Antibody (6D3F6) [NBP3-16781] - Analysis of extracts of K-562 cells, using SOCS-2 Rabbit mAb (NBP3-16781) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Western Blot: SOCS-2 Antibody (6D3F6) [NBP3-16781]

Western Blot: SOCS-2 Antibody (6D3F6) [NBP3-16781]

Western Blot: SOCS-2 Antibody (6D3F6) [NBP3-16781] - Analysis of extracts of various cell lines, using SOCS-2 Rabbit mAb (NBP3-16781) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 3min.
Immunohistochemistry-Paraffin: SOCS-2 Antibody (6D3F6) [NBP3-16781]

Immunohistochemistry-Paraffin: SOCS-2 Antibody (6D3F6) [NBP3-16781]

Immunohistochemistry-Paraffin: SOCS-2 Antibody (6D3F6) [NBP3-16781] - Rat lung using SOCS-2 Rabbit mAb (NBP3-16781) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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Applications for SOCS-2 Antibody (6D3F6)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50 - 1:200

Immunohistochemistry

1:50 - 1:200

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.3), 50% glycerol, 0.05% BSA

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SOCS-2

Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules TermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previouslyunrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCSfamily appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

Long Name

Suppressor Of Cytokine Signaling 2

Alternate Names

CIS2, Cish2, SOCS2, SSI2, STATI2

Gene Symbol

SOCS2

Additional SOCS-2 Products

Product Documents for SOCS-2 Antibody (6D3F6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SOCS-2 Antibody (6D3F6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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