Key Product Details

Species Reactivity

Mouse

Applications

Blockade of Receptor-ligand Interaction, Western Blot

Label

Janelia Fluor 549

Antibody Source

Monoclonal Rat IgG2A Clone # 62526

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PlGF-2 Antibodies »

Product Specifications

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse PlGF-2
Ala24-Pro158
Accession # P49764

Specificity

Detects mouse PlGF-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) PlGF or rhVEGF is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for PlGF-2 Antibody (62526) [Janelia Fluor® 549]

Application
Recommended Usage

Blockade of Receptor-ligand Interaction

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PlGF-2

Placenta growth factor (PlGF) is a dimeric growth factor in the PDGF/VEGF family. Alternative splicing generates at least three human PlGF isoforms PlGF 1, PlGF 2, and PlGF 3. PlGF 2 is the only isoform that contains a heparin binding region. It is expressed by villous trophoblasts, decidual cells, erythroblasts, keratinocytes, and some endothelial cells. PlGF competes with VEGF for binding and activating VEGF R1/Flt 1. This results in increased angiogenesis by making more VEGF available for activation of VEGF R2. PlGF 2 also exhibits heparin dependent binding of Neuropilins-1 and 2 which serve as VEGF co-receptors. It can inhibit nerve growth cone collapse and induce monocyte production of inflammatory cytokines including VEGF.

Long Name

Placenta Growth Factor 2

Alternate Names

PlGF2

Gene Symbol

PGF

Additional PlGF-2 Products

Product Documents for PlGF-2 Antibody (62526) [Janelia Fluor® 549]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PlGF-2 Antibody (62526) [Janelia Fluor® 549]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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