MTH1 Antibody (23GB4060)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51247

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NBP3-51247-100ul
NBP3-51247-20ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB4060

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MTH1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human MTH1 (Uniprot: P36639)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MTH1 Antibody (23GB4060)

MTH1 Antibody (23GB4060)

Immunocytochemistry/ Immunofluorescence: MTH1 Antibody (23GB4060)[NBP3-51247] -

MTH1 antibody (1:1,000), Top panel: wild-type (WT); Bottom panal: Nudix hydrolase 1 shRNA knockdown (KD). Nuclei were stained blue with DAPINudix hydrolase 1 was stained magenta with Alexa Fluor(R) 647. Scale bar, 20 um.
MTH1 Antibody (23GB4060)

Immunocytochemistry/ Immunofluorescence: MTH1 Antibody (23GB4060)[NBP3-51247] -

Immunocytochemical staining of HeLa cells with MTH1 antibody (1:1,000). Nuclei were stained blue with DAPI; MTH1 was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
MTH1 Antibody (23GB4060)

Flow Cytometry: MTH1 Antibody (23GB4060)[NBP3-51247] -

Validation of MTH1 knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with MTH1 antibody (1:2,000) and analyzed using BD flow cytometer.
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Applications for MTH1 Antibody (23GB4060)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MTH1

Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) appears to be important as it can pair with cytosine and adenine and G:C to T:A transversion mutation occurs. A significant amount of 8-OxoG is formed in the chromosomal DNA of mammalian cells, with most damaged nucleotides excised from the DNA and excreted in the urine. Along with 8-oxoG being present in oxidatively damaged DNA, 8-oxo-deoxyguanosine (8-oxo-dGTP) is formed in the nucleotide pool during normal cellular metabolism and following oxidative stress. The 8-oxo-dGTP nucleotide can be incorporated in DNA during polymerization and can result in a mispairing unless repaired. MTH converts 8-oxo-dGTP in the nucleotide pool to the monophosphate and prevents the misincorporation of 8-oxo-dGTP into DNA (Figure courtesy of Dr. Mark Kelley). MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA during gene transcription leading to missense or nonsense protein production.

Long Name

Oxidized purine nucleoside triphosphate hydrolase

Alternate Names

8-oxo-dGTPase, EC 3.6.1.-, EC 3.6.1.56, Nudix motif 1, NUDT1

Gene Symbol

NUDT1

Additional MTH1 Products

Product Documents for MTH1 Antibody (23GB4060)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MTH1 Antibody (23GB4060)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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