MAG/Siglec-4a Antibody (24GB525)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50533

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NBP3-50533-100ul
NBP3-50533-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB525

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MAG/Siglec-4a Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human MAG/Siglec-4a (Uniprot: P20916)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAG/Siglec-4a Antibody (24GB525)

MAG/Siglec-4a Antibody (24GB525)

Immunocytochemistry/ Immunofluorescence: MAG/Siglec-4a Antibody (24GB525)[NBP3-50533] -

Immunocytochemical staining of HeLa cells with MAG/Siglec-4a antibody (1:1,000) . Nuclei were stained blue with DAPI; MAG/Siglec-4a was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
MAG/Siglec-4a Antibody (24GB525)

Flow Cytometry: MAG/Siglec-4a Antibody (24GB525)[NBP3-50533] -

Flow cytometric analysis of MAG/Siglec-4aexpression in HeLa cells using MAG/Siglec-4a antibody (1:2,000). Green, isotype control; red, Myelin associated glycoprotein.
MAG/Siglec-4a Antibody (24GB525)

Western Blot: MAG/Siglec-4a Antibody (24GB525)[NBP3-50533] -

Western blotting analysis using MAG/Siglec-4a antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for MAG/Siglec-4a Antibody (24GB525)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MAG/Siglec-4a

Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).

Long Name

Myelin-associated Glycoprotein

Alternate Names

Siglec-4a, Siglec4a

Gene Symbol

MAG

Additional MAG/Siglec-4a Products

Product Documents for MAG/Siglec-4a Antibody (24GB525)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for MAG/Siglec-4a Antibody (24GB525)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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