Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Lass5 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human LASS5. The immunogen is located within the first 50 amino acids of LASS5. Amino Acid Squence: EGPADGYGYPRGRH

Specificity

Multiple isoforms of LASS5 are known to exist. This antibody is predicted not to cross-react with the highly homologous LASS6.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit Lass5 Antibody - BSA Free (NBP1-76964) is a polyclonal antibody validated for use in IHC, WB and ELISA. Anti-Lass5 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Lass5 Antibody - BSA Free

Western Blot: Lass5 AntibodyBSA Free [NBP1-76964]

Western Blot: Lass5 AntibodyBSA Free [NBP1-76964]

Western Blot: Lass5 Antibody [NBP1-76964] - SK-N-SH lysate with LASS5 antibody at (A) 1 and (B) 2 ug/ml.
Western Blot: Lass5 AntibodyBSA Free [NBP1-76964]

Western Blot: Lass5 AntibodyBSA Free [NBP1-76964]

Western Blot: Lass5 Antibody [NBP1-76964] - Human neuroblastoma cell lines untreated or treated with various drugs. Image from verified customer review.
Lass5 Antibody - BSA Free

Immunohistochemistry: Lass5 Antibody - BSA Free [NBP1-76964] -

Immunohistochemistry: Lass5 Antibody - BSA Free [NBP1-76964] - Immunohistochemistry of Lass5 in mouse brain tissue with Lass5 antibody at 2.5 ug/mL.

Applications for Lass5 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

2.5 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Lass5

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis. Multiple isoforms of LASS5 are known to exist. This antibody is predicted not to cross-react with the highly homologous LASS6.

Alternate Names

CerS5, FLJ25304, LAG1 homolog, ceramide synthase 5, LAG1 longevity assurance homolog 5, LAG1 longevity assurance homolog 5 (S. cerevisiae), MGC45411, Trh4

Gene Symbol

CERS5

UniProt

NP_671723 (Human)

Additional Lass5 Products

Product Documents for Lass5 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Lass5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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