Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44448

Novus Biologicals, part of Bio-Techne

Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL7319

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all Integrin beta 3/CD61 Antibodies »

Product Specifications

Immunogen

This antibody was generated using a recombinant protein sequence of P05106, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free

Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody [NBP3-44448]

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody [NBP3-44448]

Analysis in human thyroid gland and pancreas tissues using NBP3-44448 antibody. Corresponding Integrin beta 3/CD61 RNA-seq data are presented for the same tissues.
Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody [NBP3-44448]

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody [NBP3-44448]

Staining of human placenta shows moderate membranous immunoreactivity in trophoblastic cells, as well as positivity in blood vessels.
Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody [NBP3-44448]

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody [NBP3-44448]

Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
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Applications for Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS with Trehalose

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin beta 3/CD61

Platelet membrane glycoprotein Integrin beta-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3).

Alternate Names

CD61, GP3A, GPIIIA, INGRB3, ITGB3

Gene Symbol

ITGB3

Additional Integrin beta 3/CD61 Products

Product Documents for Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Integrin beta 3/CD61 Antibody (CL7319) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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