Integrin alpha 4 beta 1 Antibody (Hu114) [Alexa Fluor® 532]
Novus Biologicals, part of Bio-Techne | Catalog # FAB10603X
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Concentration
Product Specifications
Immunogen
Specificity
Clonality
Host
Isotype
Applications for Integrin alpha 4 beta 1 Antibody (Hu114) [Alexa Fluor® 532]
CyTOF-ready
Flow Cytometry
Formulation, Preparation, and Storage
Purification
Formulation
Preservative
Concentration
Shipping
Stability & Storage
Background: Integrin alpha 4 beta 1
Integrin alpha 4 beta 1, also known as VLA-4, is an Integrin family adhesion receptor that shares the beta 1 subunit with eleven other family members and the alpha 4 subunit with Integrin alpha 4 beta 7. The noncovalent heterodimer of alpha 4/CD49d and beta 1/CD29 subunits mediates cell adhesion to VCAM-1/CD106 on other cells and the CS-1 fragment of Fibronectin in the extracellular matrix. Leukocytes (except for neutrophils), erythroid precursors, and some non-hematopoietic cells such as epicardial, endothelial and smooth muscle precursors, Schwann cells, and chorionic cells express a4b1. In the adult, a4b1 primarily regulates immune cell migration. Circulating leukocyte a4b1 is rapidly activated by inflamed endothelial cells that present VCAM-1 and chemokines such as CXCL12/SDF-1. This activation facilitates rolling, firm adhesion, and extravasation. During immune cell activation, a4b1 can function as a costimulatory molecule.
Alternate Names
Gene Symbol
Additional Integrin alpha 4 beta 1 Products
Product Documents for Integrin alpha 4 beta 1 Antibody (Hu114) [Alexa Fluor® 532]
Product Specific Notices for Integrin alpha 4 beta 1 Antibody (Hu114) [Alexa Fluor® 532]
Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.