Human Phospho-ErbB3/Her3 (Y1262) Alexa Fluor® 647-conjugated Antibody

Name: Human Phospho-ErbB3/Her3 (Y1262) Alexa Fluor® 647-conjugated Antibody
Brand: R&D Systems
SKU: AF5817R

R&D Systems, part of Bio-Techne | Catalog # AF5817R

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Product Datasheet / COA

Key Product Details

Species Reactivity:

Human

Immunogen:

Phosphopeptide containing human ErbB3 Y1262 site

Applications:

Western Blot

Label:

Alexa Fluor 647 (Excitation=650 nm, Emission=668 nm)

Specificity:

Detects human ErbB3 when phosphorylated at Y1262 in Western blots.

View Full Technical Details for Human Phospho-ErbB3/Her3 (Y1262) Alexa Fluor® 647-conjugated Antibody

Technical Data
Citations / Reviews

Applications

	Recommended Concentration	Sample
Western Blot	Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Antigen Affinity-purified
Formulation	Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

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Background: ErbB3/Her3

ErbB3 (also known as HER3) is a type I transmembrane growth factor receptor and member of the human epidermal growth factor receptor (HER) family. ErbB3 is unique among HER family members in that it contains a defective kinase domain, and is therefore active only as a partner in a heterodimer complex with other ErbBs. Despite ErbB3's lack of intrinsic kinase activity, these heterodimers can be quite potent: the ErbB2/ErbB3 complex is considered the most active ErbB signaling dimer for the activation of downstream pathways. In addition, monomeric ErbB3 serves as a low affinity receptor for the heregulins (HRG), while ErbB2/ErbB3 heterodimers form a high affinity receptor complex. Phosphorylation of ErbB3 at Y1262 following ligand binding generates a binding site for the Grb2 adaptor protein.

Item	Value
Long Name	Receptor Tyrosine Protein Kinase ErbB3
Entrez Gene IDs	2065 (Human); 13867 (Mouse)
Alternate Names	EC 2.7.10, EC 2.7.10.1, ErbB-3, ErbB3, HER3, HER3c-erbB-3, LCCS2, MDA-BF-1, MGC88033, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB3, erbB3-S, lethal congenital contracture syndrome 2, p180-ErbB3, p45-sErbB3, p85-sErbB3, receptor tyrosine-protein kinase erbB-3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

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