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Human Phospho-CROCC (S1476) Alexa Fluor® 532-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11335X

Recombinant Monoclonal Antibody.
R&D Systems, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunocytochemistry

Label

Alexa Fluor 532 (Excitation = 534 nm, Emission = 553 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2734A

Product Specifications

Immunogen

Phosphopeptide containing the human CROCC S site 1476
Accession # Q5TZA2

Specificity

Detects Human Phospho-CROCC in direct ELISA

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CROCC

Human CROCC (also known as Rootletin) is a large coiled-coil protein that is primarily expressed in ciliated cells and plays a critical role in the organization and maintenance of the ciliary structure. Cilia are hair-like structures that protrude from the surface of many eukaryotic cells and are involved in a variety of cellular functions, including motility and signaling.CROCC is essential for forming and maintaining the rootlet and has been shown to interact with other centrosomal and ciliary proteins, such as PCM-1, C-Nap1, and CEP68. CROCC has also been shown to interact with microtubules, suggesting that it may play a role in regulating microtubule dynamics. CROCC can be Phosphorylated by NEK2 which may regulate its association with centrosomes. This antibody detects CROCC phosphorylated at Ser1476. Two alternatively spliced isoforms have been reported.

Long Name

Ciliary Rootlet Coiled-Coil, Rootletin

Alternate Names

CROCC1, KIAA0445, ROLT, TAX1BP2

Entrez Gene IDs

9696 (Human)

Gene Symbol

CROCC

UniProt

Additional CROCC Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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