Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
R&D Systems, part of Bio-Techne | Catalog # PP-H1415-0C
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human, Mouse, Transgenic Mouse
Applications
Validated:
Immunohistochemistry, Western Blot, Direct ELISA, Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Gel Supershift Assay
Cited:
Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Chromatin Immunoprecipitation (ChIP)
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # H1415
Product Specifications
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
Application
Recommended Usage
Chromatin Immunoprecipitation (ChIP)
Direct ELISA
Gel Supershift Assay
Immunohistochemistry
Immunoprecipitation
Western Blot
Background: HNF-4 alpha/NR2A1
Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.
Long Name
Hepatocyte Nuclear Factor-4, alpha
Alternate Names
HNF4 alpha, HNF4A, MODY1, NR2A1, TCF14
Entrez Gene IDs
3172 (Human)
Gene Symbol
HNF4A
Additional HNF-4 alpha/NR2A1 Products
Product Documents for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
Product Specific Notices for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
For research use only
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