Human CD11b/Integrin alpha M Alexa Fluor® 488-conjugated Antibody

Detects human CD11b/Integrin alpha M in direct ELISAs and Western blots. In Western blots no cross-reactivity with recombinant mouse (rm) Integrins alpha 2, alpha 3, alpha 4, alpha E or rhIntegrins alpha 5, alpha V, beta 1, beta 2, beta 3, or beta 6.

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Applications

Preparation & Storage

Spectra Viewer

Calculators

Background

Product Datasheets

Applications

	Recommended Concentration	Sample
Western Blot	Optimal dilution of this antibody should be experimentally determined.
Immunohistochemistry	Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Protein A or G purified
Formulation	Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Mass (in vial)

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Desired Reconstitution Concentration

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Background: CD11b/Integrin alpha M

The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.

Item	Value
Entrez Gene IDs	3684 (Human); 16409 (Mouse)
Alternate Names	CD11 antigen-like family member B, CD11b, CD11b antigen, CR-3 alpha chain, CR3A, CR3AMGC117044, Cell surface glycoprotein MAC-1 subunit alpha, Complement component 3 receptor 3 subunit, ITGAM, Integrin alpha M, Leukocyte adhesion receptor MO1, MAC-1, MAC1A, MO1A, Neutrophil adherence receptor, SLEB6, antigen CD11b (p170), integrin alpha-M, integrin, alpha M (complement component 3 receptor 3 subunit), macrophage antigen alpha polypeptide, neutrophil adherence receptor alpha-M subunit

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