Key Product Details

Species Reactivity

Human, Mouse, Rat, Bacteria

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Electron Microscopy

Label

DyLight 550 (Excitation = 562 nm, Emission = 576 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all FPRL1/FPR2 Antibodies »

Product Specifications

Immunogen

This FPRL1/FPR2 antibody is made to a synthetic peptide from the human FPRL1 protein (between residues 300-350) [UniProt P25090]

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 24086560). Bacteria reactivity reported in scientific literature (PMID: 31234710).

Localization

Cell membrane; Multi-pass membrane protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.

For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.

Applications for FPRL1/FPR2 Antibody [DyLight 550]

Application
Recommended Usage

Electron Microscopy

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Recommended applications are based on validated applications from the unconjugated base product NLS1878. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

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Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: FPRL1/FPR2

Formyl peptide receptor-like receptor 1 (FPRL1), a chemo-attractant receptor also called Lipoxin A4 Receptor (LXA4R), functions as a component of the inflammatory response. The stimulation of FPRL1 results in neutrophil activation and desensitization of chemokine receptors in monocytes (PubMed ID: 11015447). The FPRL1 receptor is up-regulated by interleukin-1 in normal human synovial fibroblasts. The immunodeficiency virus type 1 (HIV-1) envelope protein gp41 can activate the innate host immune cells through FPRL1 and induces directional migration and calcium mobilization in human monocytes and neutrophils. FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. Expressed sequence tags (ESTs) for FPRL1 have been isolated from blood, leukocyte, lung, and placenta libraries. Recently, FPRL1 has been implicated in Alzheimers Disease. Note that Formyl peptide receptor-like receptor 1 (FPRL1) and Formyl peptide receptor 2 (FPR2) are the same, but FPR2 is distinct from FPRL2.

Long Name

Formyl Peptide Receptor-like 1

Alternate Names

ALXR, FMLP-R-I, FPR2, HM63, LXA4 Receptor, RFP

Gene Symbol

FPR2

Additional FPRL1/FPR2 Products

Product Documents for FPRL1/FPR2 Antibody [DyLight 550]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for FPRL1/FPR2 Antibody [DyLight 550]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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