Elk-1 Antibody (7E10D5)

Novus Biologicals, part of Bio-Techne | Catalog # NB110-60513

Novus Biologicals, part of Bio-Techne
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NB110-60513-0.025mg
NB110-60513
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 7E10D5

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Elk-1 Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of Elk-1 expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Elk-1 Antibody (7E10D5)

Western Blot: Elk-1 Antibody (7E10D5)BSA Free [NB110-60513]

Western Blot: Elk-1 Antibody (7E10D5)BSA Free [NB110-60513]

Western Blot: Elk-1 Antibody (7E10D5) [NB110-60513] - Analysis using anti-ELK1 monoclonal antibody against truncated ELK1 recombinant protein(1) and K562 cell lysate(2).

Applications for Elk-1 Antibody (7E10D5)

Application
Recommended Usage

ELISA

1:10000

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Ascites

Formulation

Ascites

Preservative

0.03% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Elk-1

The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.

Alternate Names

Elk1

Entrez Gene IDs

2002 (Human)

Gene Symbol

ELK1

Additional Elk-1 Products

Product Documents for Elk-1 Antibody (7E10D5)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Elk-1 Antibody (7E10D5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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