Key Product Details

Species Reactivity

Human, Rat

Applications

Immunohistochemistry, Western Blot

Label

DyLight 680 (Excitation = 692 nm, Emission = 712 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 599542

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DYRK2 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human DYRK2
aa 1-107
Accession # NP_003574

Specificity

Detects human and rat DYRK2 in Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for DYRK2 Antibody (599542) [DyLight 680]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: DYRK2

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 2

Alternate Names

dual specificity tyrosine-phosphorylation-regulated kinase 2, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2, EC 2.7.12, EC 2.7.12.1, FLJ21217, FLJ21365

Gene Symbol

DYRK2

Additional DYRK2 Products

Product Documents for DYRK2 Antibody (599542) [DyLight 680]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DYRK2 Antibody (599542) [DyLight 680]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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