Clusterin/APOJ Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90128

Novus Biologicals, part of Bio-Techne
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NBP1-90128
NBP1-90128-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Clusterin Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS

Reactivity Notes

Reactivity reported in scientific literature (PMID:16524965).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit Clusterin/APOJ Antibody - BSA Free (NBP1-90128) is a polyclonal antibody validated for use in IHC. Anti-Clusterin/APOJ Antibody: Cited in 3 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Clusterin/APOJ Antibody - BSA Free

Clusterin/APOJ Antibody - BSA Free Immunohistochemistry: Clusterin/APOJ Antibody - BSA Free [NBP1-90128]

Immunohistochemistry: Clusterin/APOJ Antibody - BSA Free [NBP1-90128]

Analysis in human cervix, uterine and skeletal muscle tissues using NBP1-90128 antibody. Corresponding CLU RNA-seq data are presented for the same tissues.
Clusterin/APOJ Antibody - BSA Free Immunohistochemistry: Clusterin/APOJ Antibody - BSA Free [NBP1-90128]

Immunohistochemistry: Clusterin/APOJ Antibody - BSA Free [NBP1-90128]

Staining of human cervix shows strong cytoplasmic positivity in glandular cells.
Clusterin/APOJ Antibody - BSA Free Immunohistochemistry: Clusterin/APOJ Antibody - BSA Free [NBP1-90128]

Immunohistochemistry: Clusterin/APOJ Antibody - BSA Free [NBP1-90128]

Staining of human skeletal muscle shows no positivity in myocytes as expected.
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Applications for Clusterin/APOJ Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Clusterin

Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid poly-peptide that is posttranslationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, alpha and beta, are associated through disulfide bonds. The beta subunit (also called ApoJalpha) corresponds to residues 23-227. The alpha subunit (also called ApoJbeta) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences beta-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer's disease pathogenesis.

Alternate Names

APOJ, CLI, CLU, SGP-2, SP-40, TRPM-2

Gene Symbol

CLU

Additional Clusterin Products

Product Documents for Clusterin/APOJ Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Clusterin/APOJ Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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