Claudin-18 Antibody (DM179)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48289

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-48289-100ug
NBP3-48289-10ug
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # DM179

Concentration

LYOPH mg/ml

View all Claudin-18 Antibodies »

Product Specifications

Immunogen

Claudin-18 recombinant protein expressed in mammalian cells (Accession# P56856). The exact amino acid sequence is proprietary.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).

Scientific Data Images for Claudin-18 Antibody (DM179)

Claudin-18 Antibody (DM179)

Flow Cytometry: Claudin-18 Antibody (DM179) [NBP3-48289]

Flow cytometry analysis with Anti-Claudin-18 (DM179) on HEK293 cells transfected with human Claudin-18 (Blue histogram)or HEK293 transfected with human CLDN18.1 (Green histogram)or HEK293 transfected with irrelevant protein (Red histogram).

Applications for Claudin-18 Antibody (DM179)

Application
Recommended Usage

ELISA

1:5000-10000

Flow Cytometry

1:100

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified from cell culture supernatant

Reconstitution

Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Formulation

PBS, pH 7.4, 5-8% Trehalose

Preservative

Trehalose

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: Claudin-18

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternate Names

Claudin18, CLDN18, SFTA5, SFTPJ

Gene Symbol

CLDN18

Additional Claudin-18 Products

Product Documents for Claudin-18 Antibody (DM179)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Claudin-18 Antibody (DM179)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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