Chitinase 3-like 1/YKL-40 Antibody (CL12241) - BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21212
![Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-45202315493268.jpg "Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -")
![Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-45202315534325.jpg "Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -")
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Predicted:
Mouse (100%). Backed by our 100% Guarantee.
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # CL12241
Format
BSA Free
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
This antibody was developed using a synthetic peptide derived from P36222, with the exact immunogen sequence remaining proprietary.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Description
Novus Biologicals Mouse Chitinase 3-like 1/YKL-40 Antibody (CL12241) - BSA Free (NBP3-21212) is a monoclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
Scientific Data Images for Chitinase 3-like 1/YKL-40 Antibody (CL12241) - BSA Free
Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -
Staining of human liver shows moderate granular cytoplasmic positivity in hepatocytes.![Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-4520231550315.jpg "Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -")
Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -
Staining of human cerebral cortex shows moderate granular cytoplasmic positivity in glial cells.![Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-4520231552456.jpg "Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -")
Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -
Staining of human astrocytoma shows strong cytoplasmic positivity in tumor cells.![Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-45202315491418.jpg "Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -")
![Western Blot: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-45202315485215.jpg "Western Blot: Chitinase 3-like 1 Antibody [NBP3-21212] -")
![Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -](https://resources.bio-techne.com/images/products/nbp3-21212_mouse-chitinase-3-like-1-mab-cl12241-45202315493243.jpg "Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -")
Applications for Chitinase 3-like 1/YKL-40 Antibody (CL12241) - BSA Free
Application
Recommended Usage
Immunohistochemistry
1:1000 - 1:2500
Immunohistochemistry-Paraffin
1:1000 - 1:2500
Western Blot
1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Format
BSA Free
Preservative
0.02% Sodium Azide
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: Chitinase 3-like 1/YKL-40
Chitinase 3-like 1/YKL-40 (CHI3L1), also called BRP39 in mouse, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.
Alternate Names
CHI3L1, Chitinase 3 like 1, HCgp39, YKL-40
Gene Symbol
CHI3L1
Additional Chitinase 3-like 1/YKL-40 Products
- All Products for Chitinase 3-like 1/YKL-40
- Chitinase 3-like 1/YKL-40 cDNA Clones
- Chitinase 3-like 1/YKL-40 ELISA Kits
- Chitinase 3-like 1/YKL-40 Luminex Assays
- Chitinase 3-like 1/YKL-40 Lysates
- Chitinase 3-like 1/YKL-40 Primary Antibodies
- Chitinase 3-like 1/YKL-40 Proteins and Enzymes
- Chitinase 3-like 1/YKL-40 Simple Plex
Product Documents for Chitinase 3-like 1/YKL-40 Antibody (CL12241) - BSA Free
Product Specific Notices for Chitinase 3-like 1/YKL-40 Antibody (CL12241) - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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