CEACAM6/CD66c Antibody (DMC685) - Chimeric

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48382

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-48382-100ug
NBP3-48382-10ug
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # DMC685

Concentration

LYOPH mg/ml

View all CEACAM-6/CD66c Antibodies »

Product Specifications

Immunogen

CEACAM6/CD66c recombinant protein expressed in mammalian cells (Accession# P40199). The exact amino acid sequence is proprietary.

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).

Scientific Data Images for CEACAM6/CD66c Antibody (DMC685) - Chimeric

CEACAM6/CD66c Antibody (DMC685) - Chimeric

Flow Cytometry: CEACAM6/CD66c Antibody (DMC685) - Chimeric [NBP3-48382]

Flow cytometry analysis with Anti-CEACAM6/CD66c/CD66c(DMC685) on HEK293 cells transfected with human CEACAM6/CD66c/CD66c(Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).
CEACAM6/CD66c Antibody (DMC685) - Chimeric

Flow Cytometry: CEACAM6/CD66c Antibody (DMC685) - Chimeric [NBP3-48382]

Flow cytometry analysis of antigen binding of anti-human CEACAM6 mAb(NBP3-48382). (A) NBP3-48382 does not bind to jurkat cells that do not express CEACAM6. (B) A clear peak shift of NBP3-48382 was seen compared to the control when incubated with CEACAM6-expressing SNU-5 cells, indicating strong binding of NBP3-48382 to CEACAM6. Antibodies were incubated at 5 ug/ml.

Applications for CEACAM6/CD66c Antibody (DMC685) - Chimeric

Application
Recommended Usage

Flow Cytometry

1:100

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified from cell culture supernatant

Reconstitution

Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Formulation

PBS, pH 7.4, 5-8% Trehalose

Preservative

Trehalose

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: CEACAM-6/CD66c

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. CEACAM 6 expression is strongly up-regulated already during early stages of adenocarcinoma formation e.g. in colon. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

Long Name

Carcinoembryonic Antigen-related Cell Adhesion Molecule 6

Alternate Names

CD66c, CEACAM6, CEAL, NCA

Gene Symbol

CEACAM6

Additional CEACAM-6/CD66c Products

Product Documents for CEACAM6/CD66c Antibody (DMC685) - Chimeric

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CEACAM6/CD66c Antibody (DMC685) - Chimeric

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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