Caspase-2 Antibody [Alexa Fluor® 700]
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26612AF700
Key Product Details
Species Reactivity
Validated:
Predicted:
Applications
Label
Antibody Source
Concentration
Product Specifications
Immunogen
Reactivity Notes
Specificity
Clonality
Host
Isotype
Applications for Caspase-2 Antibody [Alexa Fluor® 700]
ELISA
Immunocytochemistry/ Immunofluorescence
Western Blot
Formulation, Preparation, and Storage
Purification
Formulation
Preservative
Concentration
Shipping
Stability & Storage
Background: Caspase-2
Caspase-2, also known as NEDD2 and ICH-1, is a 30‑32 kDa member of the peptidase C14A/IL‑1 beta‑converting family of enzymes. It is widely expressed and is an integral component of the apoptotic cascade. Caspase-2 is a disulfide-linked homodimer, with activation occurring following oligomerization within the context of activating platforms such as DISC (death-inducing signaling complex) or the PIDDosome. Initially, Pro-Caspase-2 is cleaved into a p34 subunit and a p14 subunit which are further processed to generate the prodomain, plus the mature p18 and p12 subunits. Notably, each p18-p12 heterodimer demonstrates proteolytic activity and localizes to either the nucleus or cytoplasm.
Alternate Names
Gene Symbol
Additional Caspase-2 Products
Product Documents for Caspase-2 Antibody [Alexa Fluor® 700]
Product Specific Notices for Caspase-2 Antibody [Alexa Fluor® 700]
Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.