Borealin Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77330

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NBP1-77330-0.025mg
NBP1-77330
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Conjugate
Catalog #
Alexa Fluor 350
NBP1-77330AF350
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Alexa Fluor 405
NBP1-77330AF405
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Alexa Fluor 488
NBP1-77330AF488
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Alexa Fluor 532
NBP1-77330AF532
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Alexa Fluor 594
NBP1-77330AF594
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Alexa Fluor 647
NBP1-77330AF647
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Alexa Fluor 700
NBP1-77330AF700
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Alexa Fluor 750
NBP1-77330AF750
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Alexa Fluor Plus 405
NBP1-77330AFP405
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Alexa Fluor Plus 488
NBP1-77330AFP488
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Alexa Fluor Plus 555
NBP1-77330AFP555
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Alexa Fluor Plus 594
NBP1-77330AFP594
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Alexa Fluor Plus 647
NBP1-77330AFP647
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Alexa Fluor Plus 680
NBP1-77330AFP680
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Allophycocyanin
NBP1-77330APC
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Biotin
NBP1-77330B
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CoraFluor 1
NBP1-77330CL1
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DyLight 350
NBP1-77330UV
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DyLight 405
NBP1-77330V
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DyLight 488
NBP1-77330G
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DyLight 550
NBP1-77330R
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DyLight 594
NBP1-77330DL594
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DyLight 650
NBP1-77330C
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DyLight 680
NBP1-77330FR
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DyLight 755
NBP1-77330IR
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FITC
NBP1-77330F
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HRP
NBP1-77330H
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Janelia Fluor 525
NBP1-77330JF525
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Janelia Fluor 549
NBP1-77330JF549
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Janelia Fluor 646
NBP1-77330JF646
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Janelia Fluor 669
NBP1-77330JF669
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mFluor Violet 450 SE
NBP1-77330MFV450
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mFluor Violet 500 SE
NBP1-77330MFV500
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mFluor Violet 610 SE
NBP1-77330MFV610
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PE
NBP1-77330PE
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PerCP
NBP1-77330PCP
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Borealin Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8. The immunogen is located within the first 50 amino acids of CDCA8.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Borealin Antibody - BSA Free

Western Blot: Borealin AntibodyBSA Free [NBP1-77330]

Western Blot: Borealin AntibodyBSA Free [NBP1-77330]

Western Blot: Borealin Antibody [NBP1-77330] - Rat kidney lysate with Borealin antibody at (A) 1 and (B) 2 ug/ml.
Borealin Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Borealin Antibody - BSA Free [NBP1-77330] -

Immunocytochemistry/ Immunofluorescence: Borealin Antibody - BSA Free [NBP1-77330] - Immunofluorescence of Borealin in Rat Kidney cells with Borealin antibody at 20 ug/mL.

Applications for Borealin Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Borealin

CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.

Alternate Names

BOR, BOREALIN, cell division cycle associated 8, Cell division cycle-associated protein 8, Dasra B, DasraB, dasra-B, FLJ10468, FLJ12042, hDasra-B, MESRGP, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein

Entrez Gene IDs

55143 (Human); 52276 (Mouse); 500545 (Rat)

Gene Symbol

CDCA8

UniProt

Q53HL2 (Human)

Additional Borealin Products

Product Documents for Borealin Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Borealin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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