Bone morphogenic proteins (BMPs) are members of the TGFbeta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFbeta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.

Long Name

Bone Morphogenetic Protein 5

Alternate Names

BMP5

Gene Symbol

BMP5

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Product Documents for BMP-5 Antibody (781321) [DyLight 550]

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Product Specific Notices for BMP-5 Antibody (781321) [DyLight 550]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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BMP-5 Antibody (781321) [DyLight 550]

Novus Biologicals, part of Bio-Techne | Catalog # FAB6176L

Key Product Details

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Applications for BMP-5 Antibody (781321) [DyLight 550]

Neutralization

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Background: BMP-5