Aconitase 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51965

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NBP1-51965
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Aconitase 1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QVDFNRRADSLQKNQ corresponding to internal region according to NP_002188.1.

Epitope

C-QVDFNRRADSLQKNQ

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Aconitase 1 Antibody

Western Blot: Aconitase 1 Antibody [NBP1-51965]

Western Blot: Aconitase 1 Antibody [NBP1-51965]

Western Blot: Aconitase 1 Antibody [NBP1-51965] - NBP1-51965 (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Aconitase 1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 100 kDa band observed in human liver lysates (calculated MW of 98.4 kDa band according to NP_002188.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Aconitase 1

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Alternate Names

Aconitase, aconitase 1, soluble, aconitate hydratase, Citrate hydro-lyase, cytoplasmic aconitate hydratase, EC 4.2.1, EC 4.2.1.3, Ferritin repressor protein, IREB1IREBP1, IREBP, IRE-BP 1, Iron regulatory protein 1, iron-responsive element binding protein 1, Iron-responsive element-binding protein 1, IRP1ACONS

Entrez Gene IDs

48 (Human); 11428 (Mouse); 50655 (Rat)

Gene Symbol

ACO1

UniProt

NP_002188.1 (Human)

Additional Aconitase 1 Products

Product Documents for Aconitase 1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Aconitase 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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