Webinar: 10 Minute Charge Heterogeneity Analysis for Development and Quality Control of Biopharmaceuticals

Determination of protein isoelectric points and charge isoforms are critical steps in protein characterization and biopharmaceutical development. Charge variants commonly occur as a result of posttranslational modification including glycosylation, glycation of lysine residues, amidation, sialylation, and oxidation. These changes can affect biological activity, patient safety, and drug stability.

In this webinar Carrie L. Anderson, Senior Scientist, Vaccine Analytical Development, Merck & Co. will present the wide range of applications for icIEF in biopharmaceutical development and demonstrate how icIEF increases the efficiency of process and formulation development. Karan Shah, Senior Research Associate, Immunogen will review the challenges of analyzing antibody drug conjugates (ADC) and present how icIEF allows them to monitor both the charge heterogeneity profile and quantitate the amount of unconjugated antibody present in a ADC sample.

Speakers

Carrie Anderson, Senior Scientist, Merck

Karan Shah, Senior Research Associate, Immunogen

Scott Mack, Senior Scientist, ProteinSimple