Webinar: A Streamlined Approach to icIEF Method Development

Determination of isoelectric points and charge isoforms are critical steps in protein characterization for biopharmaceutical and vaccine development. Biogen's Analytical Development (AD) group applied Quality by Design (QbD) and Computer-Aided Design of Experiments (DoE) approaches for icIEF assay development and qualification of a challenging IgG molecule. This innovative computer-aided DoE and a 96-well plate coupled with automated sample preparation enabled the AD group to meet development timelines for multiple products.

In the webinar, Richard will present the DoE principles and approach to icIEF method development and optimization. He will also discuss the software upgrades to assist in high throughput method development, including automated sample preparation.

Speaker

Richard Smart, Senior Associate Scientist, Technical Development, Biogen