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What is Armored RNA Technology?

Armored RNA® and Armored DNA technologies stabilize and protect nucleic acids from nuclease degradation by packaging them in a protective protein coat. Armored reagents deliver several end-user benefits, including:

Optimized Workflow

Armored RNA, Armored RNA Quant and Armored DNA Quant controls can be added directly to human matrices as an exogenous internal control for extraction with most nucleic acid isolation methods and detection in molecular assays.

Flexibility

Nuclease-resistant protein coat can also be removed by heat lysis for direct detection as a positive run control. For Armored RNA Quant and Armored DNA Quant, analytical quantification is performed with a validated method referencing a NIST-traceable phosphate standard.

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cGMP-Compliant Armored Molecular Controls

When designing molecular assays for diagnostic or clinical application, incorporating Current Good Manufacturing Practices (cGMP) control products is crucial to ensure assays align with regulatory requirements to produce accurate, reliable, and reproducible results.

Armored technology stabilizes and protects nucleic acids from nuclease degradation by packaging targets in a protective protein coat, providing a non-infectious molecular control that can monitor the complete molecular assay workflow from extraction to detection.

Catalog of Armored RNA and Armored DNA Products

Armored RNA Quant®

Each control encodes in vitro transcribed RNA encapsulated in a protective protein coat to create a virus-like particle resistant to nuclease degradation.

SARS-CoV-2

DescriptionConfigurationPart #cGMP
Targets the Nucleocapsid 1 and Nucleocapsid 2 regions of the CDC recommended Diagnostic Panel (CDC-006-00019).1x106 cp/mL 250μL52151    ●

SARS-CoV-2 Panel

DescriptionConfigurationPart #cGMP
Contains multiple regions of SARS-Cov-2 genome including nucleocapsid, envelope, RNA-dependent RNA polymerase, open reading frame 1, and human RNAse P as an internal control.1x106 cp/mL 250μL52153 

SARS-CoV-2 Spike Variants

DescriptionConfigurationPart #cGMP
Targets mutations in the SARS CoV-2 spike protein prevalent in the Alpha (B.1.1.7), Beta (B.1.351), Gamma (B.1.1.28), Delta (B.1.617.2), and Omicron (B.1.1.529) strains.1x106 cp/mL 250μL52160/52154 

Respiratory Triplex

DescriptionConfigurationPart #cGMP
Contains regions of SARS-Cov-2, Influenza A (H1N1, H3N2, and H7N9), Influenza B, Respiratory Syncytial Virus A (RSVA), Respiratory Syncytial Virus B (RSVB), and RPP30 as an internal control.1x108 cp/mL 250μL52108 

Armored RNA Quant® EPA 1615 Controls

DescriptionConfigurationPart #cGMP
Contains sequences detected by the Enterovirus, Norwalk GI, and Norwalk GII virus assays described in EPA Method 1615 - Measurement of Enterovirus and Norovirus occurrence in water by culture and RT-qPCR.1x1012 cp/mL 500μL52000 

Enterovirus

DescriptionConfigurationPart #cGMP
Contains sequences amplified by primer binding regions for polio virus (type I Sabin), coxsackievirus A and coxsackievirus B (Schwab, et al., 1995 and Rotbart, 1990).5x105 cp/mL 5x100μL42102    ●

Download Enterovirus PDF

 

 

Pentavalent Arbovirus Control

(CHIKV,DENV,WNV,YFV,ZIKV)
DescriptionConfigurationPart #cGMP
Targets regions of the Chikungunya, Dengue, West Nile, Yellow Fever, and Zika viruses.1x108 cp/mL 500μL49659    ●

Download the Pentavalent Arbovirus Control PDF

 

 

Internal Process Control (Armored RNA Quant)

DescriptionConfigurationPart #cGMP 
Targets a non-specific, 1,000 nucleotides in vitro transcribed RNA (non-homologous) sequence intended to be used as a spike-in to sample (e.g., urine, blood, CSF, plasma/liquid biopsy) to monitor the overall efficiency of a testing process. 2x106 cp/mL 500μL49650  

Download the Internal Process Control PDF

 

 

RNase P

DescriptionConfigurationPart #cGMP
Targets the human RNase P gene; often used as an internal control because abundant copies in the human genome make it readily detectable.1x106 cp/mL 500μL52152 

Armored DNA Quant

Armored DNA  technology stabilizes and protects nucleic acids from nuclease degradation by packaging them in a protective protein coat. Encapsulated as non-infectious, nuclease-resistant, pseudo-viral particle.

Mpox Nonvariola Orthopox Control

DescriptionConfigurationPart #cGMP
A single, concatenated construct of both nonvariola Orthopox and Mpox-specific sequence blended with with RNAse P to allow for an all-in-one process control. The control is provided as two tubes of high and low concentration along with diluent for convenience.500μL49670    ●

Download the Mpox/Nonvariola Orthopox Control PDF

 

 

Internal Process Control (Armored DNA Quant)

DescriptionConfigurationPart #cGMP
Targets a non-specific, 495 base pair in vitro transcribed DNA (non-homologous) sequence intended to be used as a spike-in to sample (e.g., urine, blood, CSF, plasma/liquid biopsy) to monitor the overall efficiency of a testing process.1x108 cp/mL 500μL52003 

Armored RNA®

Hepatitis G Virus

DescriptionConfigurationPart #cGMP
Contains sequences amplified by primer binding regions for Hepatitis G Virus (Schlueter, 1996); the PCR product generated is 185 nucleotides.250μL42024    ●

Download the Hepatitis G Virus PDF

 

 

Enterovirus

DescriptionConfigurationPart #cGMP
Contains sequences amplified by primer binding regions for polio virus (type I Sabin), coxsackievirus A and coxsackievirus B (Schwab, et al., 1995 and Rotbart, 1990).250μL42050    ●

Download the Enterovirus PDF

 

 

Armored RNA Quant Made-to-Order

Bacteriophage MS2

DescriptionPart #
Bacteriophage MS252223

 

 

Beta-Actin (ACTB)

DescriptionPart #
Beta-Actin (ACTB)52225

Ebolavirus

DescriptionPart #
Ebolavirus52217

Glucuronidase Beta (GUSB)

DescriptionPart #
Glucuronidase Beta (GUSB)52224

Hepatitis C Virus (GT 2b)

DescriptionPart #
Hepatitis C Virus (GT 2b)42101

Download the Hepatitis C Virus (GT 2b) PDF

 

 

Hepatitis D Virus

DescriptionPart #
Hepatitis D Virus52212

HIV (Subtype B)

DescriptionPart #
HIV (Subtype B)42103

Human Papillomavirus 16

DescriptionPart #
Human Papillomavirus 1652219

Human Papillomavirus 18

DescriptionPart #
Human Papillomavirus 1852220

Sapovirus I, II, IV

DescriptionPart #
Sapovirus I, II, IV52221

Sapovirus V

DescriptionPart #
Sapovirus V52222

Sudan Ebolavirus

DescriptionPart #
Sudan Ebolavirus52218

Armored RNA® Made-to-Order

Dengue Virus (Type I)

DescriptionPart #
Dengue Virus (Type I)42044

Hepatitis C Virus (GT 1a)

DescriptionPart #
Hepatitis C Virus (GT 1a)42004

Hepatitis C Virus (GT 1b)

DescriptionPart #
Hepatitis C Virus (GT 1b)42006

Hepatitis C Virus (GT 2a/c)

DescriptionPart #
Hepatitis C Virus (GT 2a/c)42008

Hepatitis C Virus (GT 2b)

DescriptionPart #
Hepatitis C Virus (GT 2b)42010

Hepatitis C Virus (GT 3a)

DescriptionPart #
Hepatitis C Virus (GT 3a)42012

HIV (Subtype B)

DescriptionPart #
HIV (Subtype B)42000

Norovirus GI

DescriptionPart #
Norovirus GI42030

Norovirus GII

DescriptionPart #
Norovirus GII42032

SARS (BNI-1)

DescriptionPart #
SARS (BNI-1)42090

SARS (CoV-NC)

DescriptionPart #
SARS (CoV-NC)42091

West Nile Virus (Cap)

DescriptionPart #
West Nile Virus (Cap)42042

West Nile Virus (HNY1999)

DescriptionPart #
West Nile Virus (HNY1999)42040

West Nile Virus (NEN)

DescriptionPart #
West Nile Virus (NEN)42041

Molecular Assay Reagents

RNARetain Buffer

DescriptionPart #Configuration
Intended for the collection, storage, and transportation of fresh tissue specimens for subsequent RNA isolation and further molecular testing. Eliminates the need to immediately process specimens, enabling RNA extraction and molecular testing at a later time and/or transport to a different location.49536Volume 2L

Variable concentrations, volumes and vial quantities available upon request

TSMIII Buffer

DescriptionPart #Configuration
A buffered solution ideally suited for the dilution of Armored products. The additives provide stability to the protein-coated nucleic acid through multiple freeze-thaws when stored properly, allowing for more flexible and scalable testing processes.49600Volume 50mL

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