NFkB/IkB Inhibitors: Small Molecules and Peptides
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
25 results for "NFkB/IkB Inhibitors Small Molecules and Peptides" in Products
25 results for "NFkB/IkB Inhibitors Small Molecules and Peptides" in Products
NFkB/IkB Inhibitors: Small Molecules and Peptides
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
Potent farnesyl diphosphate (FPP) synthase inhibitor
| Alternate Names: | Zometa |
| Chemical Name: | [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid |
| Purity: | ≥98% (HPLC) |
Proteasome and calpain inhibitor. Inhibits NF-κB activation
| Alternate Names: | Z-LLL-al,Z-Leu-Leu-Leu-CHO |
| Chemical Name: | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Purity: | ≥95% (HPLC) |
Specific inhibitor of NF-κB activation
| Alternate Names: | CAPE |
| Chemical Name: | 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester |
| Purity: | ≥98% (HPLC) |
Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
| Alternate Names: | Bay 11-7083 |
| Chemical Name: | (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile |
| Purity: | ≥98% (HPLC) |
Potent, selective inhibitor of IKKβ
| Chemical Name: | 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide |
| Purity: | ≥97% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of TBK
| Chemical Name: | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid |
| Purity: | ≥98% (HPLC) |
Selective allosteric inhibitor of IKK; anti-inflammatory
| Chemical Name: | N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Inhibitor of NF-κB activation; anti-inflammatory
| Chemical Name: | (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
TRAF6-Ubc13 interaction inhibitor
| Chemical Name: | 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone |
| Purity: | ≥98% (HPLC) |
Selective IKKα and IKKβ inhibitor
| Chemical Name: | 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile |
| Purity: | ≥97% (HPLC) |
Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
| Alternate Names: | (-)-Arctigenin |
| Chemical Name: | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone |
| Purity: | ≥98% (HPLC) |
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
| Chemical Name: | 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid |
| Purity: | ≥97% (HPLC) |
Anti-inflammatory, antioxidant and free radical scavenger
| Alternate Names: | 3',4',5,7-Tetrahydroxyflavone |
| Chemical Name: | 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of IKK
| Chemical Name: | N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Novel IKK2-selective inhibitor
| Chemical Name: | N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective IKKβ inhibitor
| Chemical Name: | 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide |
| Purity: | ≥98% (HPLC) |
NF-κB and AP-1 dual inhibitor
| Chemical Name: | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Inhibits TNF-α-induced NF-κB activation
| Chemical Name: | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
| Purity: | ≥98% (HPLC) |
Inhibitor of IKKβ; also exhibits antibacterial activity
| Chemical Name: | N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide |
| Purity: | ≥98% (HPLC) |
High affinity antagonist of RAGE
| Chemical Name: | 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide |
| Purity: | ≥98% (HPLC) |
Potent and selective IKKε inhibitor
| Chemical Name: | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile |
| Purity: | ≥98% (HPLC) |
Nurr1 activator; inhibits NF-κB-dependent gene expression
| Chemical Name: | 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole] |
| Purity: | ≥98% (HPLC) |
Potent NIK inhibitor
| Chemical Name: | 4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol |
| Purity: | ≥98% |
Potent Nurr1 activator
| Chemical Name: | 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one |
| Purity: | ≥98% (HPLC) |
