FPS ZM1
Tocris Bioscience, part of Bio-Techne | Catalog # 6237
High affinity antagonist of RAGE
Product Description
FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.Product Specifications
Molecular Weight
327.85
Formula
C20H22ClNO
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
CAS Number
945714-67-0
PubChem ID
24752728
InChI Key
XDFKWGIBQMHSOH-UHFFFAOYSA-N
SMILES
ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.78 | 100 | |
| Ethanol | 32.78 | 100 |
Preparing Stock Solutions
for FPS ZM1
The following data is based on the product molecular weight 327.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.05 mL | 15.25 mL | 30.50 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.10 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.05 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hong Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-beta Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem.Res. 2016 PMID: 26738988
- Deane A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease. J.Clin.Invest. 2012 PMID: 22406537
Product Specific Notices for FPS ZM1
For research use only
Loading...
Loading...
Loading...