IP7e

Name: IP7e
Brand: Tocris Bioscience
SKU: 5699

Tocris Bioscience, part of Bio-Techne | Catalog # 5699

Citations (4)

COA / SDS

Potent Nurr1 activator

Key Product Details

Description:	Potent Nurr1 activator
Chemical Name:	6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	390.43

View Full Technical Details for IP7e

Technical Data
Citations

Biological Activity for IP7e

IP7e is a potent Nurr1 activator (EC₅₀ = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.

Compound Libraries for IP7e

IP7e is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for IP7e

M. Wt	390.43
Formula	C₂₃H₂₂N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	500164-74-9
PubChem ID	9908426
InChi Key	YCAACZFPADQMAR-UHFFFAOYSA-N
Smiles	CN1C(C2=CC=C(COCCOC)C=C2)=CC3=C(C(C4=CC=CC=C4)=NO3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IP7e

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.04	100
	ethanol	7.81	20 with gentle warming

Preparing Stock Solutions for IP7e

The following data is based on the product molecular weight 390.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Reconstitution Calculator

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References for IP7e

References are publications that support the biological activity of the product.

Montarolo Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 2014 PMID: 25265488
Hintermann Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 2007 PMID: 17035009