Caffeic acid phenethyl ester
Tocris Bioscience, part of Bio-Techne | Catalog # 2743
Specific inhibitor of NF-κB activation
Key Product Details
Description
Specific inhibitor of NF-κB activation
Alternative Names
CAPE
Product Description
Caffeic acid phenethyl ester is an antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF-κB activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.Product Specifications
Molecular Weight
284.31
Formula
C17H16O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
CAS Number
104594-70-9
PubChem ID
5281787
InChI Key
SWUARLUWKZWEBQ-VQHVLOKHSA-N
SMILES
OC1=C(O)C=C(/C=C/C(OCCC2=CC=CC=C2)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.43 | 100 | |
| Ethanol | 28.43 | 100 |
Preparing Stock Solutions
for Caffeic acid phenethyl ester
The following data is based on the product molecular weight 284.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.70 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fitzpatrick Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J.Pharmacol.Exp.Ther. 2001 PMID: 11714876
- Natarajan Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc.Natl.Acad.Sci.USA
- Sud'ina Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 1993 PMID: 7689063
Product Specific Notices for Caffeic acid phenethyl ester
For research use only
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