C-DIM 12

Name: C-DIM 12
Brand: Tocris Bioscience
SKU: 5821

Tocris Bioscience, part of Bio-Techne | Catalog # 5821

Citations (1)

COA / SDS

Nurr1 activator; inhibits NF-κB-dependent gene expression

Key Product Details

Description:	Nurr1 activator; inhibits NF-κB-dependent gene expression
Chemical Name:	3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Purity:	≥98% (HPLC)
Molecular Weight:	356.85

View Full Technical Details for C-DIM 12

Technical Data
Citations

Biological Activity for C-DIM 12

C-DIM 12 is a nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.

Technical Data for C-DIM 12

M. Wt	356.85
Formula	C₂₃H₁₇ClN₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	178946-89-9
PubChem ID	5302583
InChi Key	LTLRXTDMXOFBDW-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C-DIM 12

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.69	100
	ethanol	35.69	100

Preparing Stock Solutions for C-DIM 12

The following data is based on the product molecular weight 356.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	14.01 mL	28.02 mL
5 mM	0.56 mL	2.80 mL	5.60 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for C-DIM 12

References are publications that support the biological activity of the product.

De Miranda The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 2015 PMID: 25858541
De Miranda Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 2013 PMID: 23318470