Zoledronic Acid

Tocris Bioscience, part of Bio-Techne | Catalog # 6111

Potent farnesyl diphosphate (FPP) synthase inhibitor
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Key Product Details

Description

Potent farnesyl diphosphate (FPP) synthase inhibitor

Alternative Names

Zometa

View all Ras GTPase Inhibitors »

Product Description

Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Product Specifications

Molecular Weight

272.09

Formula

C5H10N2O7P2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid

CAS Number

118072-93-8

PubChem ID

68740

InChI Key

XRASPMIURGNCCH-UHFFFAOYSA-N

SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 13.6 50
water 0.68 2.5

Preparing Stock Solutions for Zoledronic Acid

The following data is based on the product molecular weight 272.09

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.35 mL 36.75 mL 73.51 mL
2.5 mM 1.47 mL 7.35 mL 14.70 mL
5 mM 0.74 mL 3.68 mL 7.35 mL
25 mM 0.15 mL 0.74 mL 1.47 mL

Calculators

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Reconstitution Calculator

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Product Documents for Zoledronic Acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Zoledronic Acid

For research use only

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