NIKi

Name: NIKi
Brand: Tocris Bioscience
SKU: 7136

Tocris Bioscience, part of Bio-Techne | Catalog # 7136

COA / SDS

Potent NIK inhibitor

Key Product Details

Description:	Potent NIK inhibitor
Chemical Name:	4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol
Purity:	≥98%
Molecular Weight:	366.42

View Full Technical Details for NIKi

Technical Data
Citations

Biological Activity for NIKi

NIKi is a potent inhibitor of NF-κB-inducing kinase (NIK) activity (IC₅₀ = 20 nM).

Technical Data for NIKi

M. Wt	366.42
Formula	C₂₀H₂₂N₄O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1202763-91-4
PubChem ID	58221375
InChi Key	ZZIZLABGKZWVAW-UHFFFAOYSA-N
Smiles	COCCOC1=CN=C(N=C1C2=CNC3=CC=C(C#CC(C)(O)C)C=C23)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NIKi

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.64	100

Preparing Stock Solutions for NIKi

The following data is based on the product molecular weight 366.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.65 mL	27.29 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.36 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Reconstitution Calculator

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References for NIKi

References are publications that support the biological activity of the product.

Li Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg.Med.Chem.Lett. 2013 PMID: 23374866