Arctigenin
Tocris Bioscience, part of Bio-Techne | Catalog # 1777
Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
Key Product Details
Description
Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
Alternative Names
(-)-Arctigenin
Product Description
Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.Product Specifications
Molecular Weight
372.42
Formula
C21H24O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
CAS Number
7770-78-7
PubChem ID
64981
InChI Key
NQWVSMVXKMHKTF-JKSUJKDBSA-N
SMILES
OC(C=C3)=C(OC)C=C3C[C@@H](C(OC2)=O)[C@H]2CC1=CC(OC)=C(OC)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.24 | 100 |
Preparing Stock Solutions
for Arctigenin
The following data is based on the product molecular weight 372.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.43 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cho Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Exp.Biol.Abstr.
- Jang Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J.Neurosci.Res. 2002 PMID: 11948668
- Schroder Differential in vitro anti-HIV activity of natural lignans. Z.Naturforsch.C. 1990 PMID: 1965681
- Cho Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Int.Immunopharmacol. 2002 PMID: 11789661
Product Specific Notices for Arctigenin
For research use only
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