Celastrol

Name: Celastrol
Brand: Tocris Bioscience
SKU: 3203

Tocris Bioscience, part of Bio-Techne | Catalog # 3203

Citations (16)

COA / SDS

Inhibits TNF-α-induced NF-κB activation

Key Product Details

Description:	Inhibits TNF-α-induced NF-κB activation
Chemical Name:	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Purity:	≥98% (HPLC)
Molecular Weight:	450.61

View Full Technical Details for Celastrol

Technical Data
Citations

Biological Activity for Celastrol

Celastrol is an antioxidant, anti-inflammatory, antitumor and neuroprotective agent. Inhibits lipid peroxidation in mitochondria, TNF-α-induced NFκB activation, peroxidase activity of peroxiredoxin 1 (IC₅₀ = 0.29 μM), and topoisomerase II activity in vitro (IC₅₀ = 7.41 μM). Celastrol treatment inhibits the growth of PC-3 tumors in mice.

Technical Data for Celastrol

M. Wt	450.61
Formula	C₂₉H₃₈O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	34157-83-0
PubChem ID	122724
InChi Key	KQJSQWZMSAGSHN-JJWQIEBTSA-N
Smiles	O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@@](O)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Celastrol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.06	100
	ethanol	33.8	75

Preparing Stock Solutions for Celastrol

The following data is based on the product molecular weight 450.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.19 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for Celastrol

References are publications that support the biological activity of the product.

Yang Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 PMID: 16651429
Xu Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct.Target Ther. 2023 PMID: 36732502
Sethi Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 2007 PMID: 17110449
Sassa The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem.Biophys.Res.Comms. 1990 PMID: 2241977
Nagase Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci.Biotechnol.Biochem. 2003 PMID: 14519971