Compounds for Stem Cell Differentiation: Small Molecules and Peptides
Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.
49 results for "Compounds for Stem Cell Differentiation Small Molecules and Peptides" in Products
49 results for "Compounds for Stem Cell Differentiation Small Molecules and Peptides" in Products
Compounds for Stem Cell Differentiation: Small Molecules and Peptides
Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity: | ≥99% (HPLC) |
Adenylyl cyclase activator
| Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one |
| Purity: | ≥98% (HPLC) |
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent AMPK inhibitor; also BMP type I receptor inhibitor
| Alternate Names: | Compound C,BML-275 |
| Chemical Name: | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
| Chemical Name: | O-(4-Hydroxy-3-iodophenyl-3,5-diiodo-L-tyrosine |
| Purity: | ≥98% (HPLC) |
Selective ALK2 inhibitor
| Chemical Name: | 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Purity: | ≥98% (HPLC) |
Anti-inflammatory glucocorticoid
| Chemical Name: | (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione |
| Purity: | ≥98% (HPLC) |
Endogenous retinoic acid receptor agonist
| Alternate Names: | Tretinoin,ATRA |
| Chemical Name: | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid |
| Purity: | ≥98% (HPLC) |
Glutathione (GSH) precursor; maintains stem cell function in culture.
| Chemical Name: | (2R)-2-Acetamido-3-sulfanylpropanoic acid |
| Purity: | ≥98% (HPLC) |
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
| Chemical Name: | 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol |
| Purity: | ≥97% (HPLC) |
Activator of LKB1/AMPK; antidiabetic agent
| Chemical Name: | N,N-Dimethylimidodicarbonimidic diamide hydrochloride |
Smo receptor agonist
| Chemical Name: | 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine |
| Purity: | ≥98% (HPLC) |
Endogenous agonist of LPA1 and LPA2
| Chemical Name: | 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt |
Synthetic retinoid; induces differentiation of stem cells
| Chemical Name: | 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid |
| Purity: | ≥99% (HPLC) |
Selective JNK inhibitor
| Chemical Name: | Anthra[1-9-cd]pyrazol-6(2H)-one |
| Purity: | ≥98% (HPLC) |
FGFR1 and -3 inhibitor
| Chemical Name: | N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
| Purity: | ≥98% (HPLC) |
Retinoic acid synthesized to Ancillary Material Grade
| Chemical Name: | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E-nonatetraenoic acid |
| Purity: | ≥98% |
5-HT reuptake inhibitor
| Chemical Name: | N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent AMPK activator
| Chemical Name: | 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Purity: | ≥98% (HPLC) |
High affinity PKC activator; also APP modulator
| Chemical Name: | (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide |
| Purity: | ≥98% (HPLC) |
LDN 193189 synthesized to cGMP guidelines
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥99% |
DAPT synthesized to Ancillary Material Grade
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
| Purity: | ≥99% |
Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
| Chemical Name: | 2-(Dihydrogen phosphate)-L-ascorbic acid sodium salt |
| Purity: | ≥95% (HPLC) |
Forskolin synthesized to Ancillary Material Grade
| Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one |
| Purity: | ≥98% |
PDE inhibitor (non-selective)
| Chemical Name: | 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione |
| Purity: | ≥98% (HPLC) |
