Metformin hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2864

Activator of LKB1/AMPK; antidiabetic agent
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Key Product Details

Description

Activator of LKB1/AMPK; antidiabetic agent

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Product Description

Metformin hydrochloride is an antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines via inhibition of mitochondrial complex I (MRC-1). Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Metformin hydrochloride prevents brain atrophy, and slows the pace of aging across diverse tissues in animal studies.

Product Specifications

Molecular Weight

165.62

Formula

C4H11N5.HCl

Storage

Store at RT

Chemical Name

N,N-Dimethylimidodicarbonimidic diamide hydrochloride

CAS Number

1115-70-4

PubChem ID

14219

InChI Key

OETHQSJEHLVLGH-UHFFFAOYSA-N

SMILES

NC(NC(N(C)C)=N)=N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.56 100
DMSO 3.31 20 with gentle warming

Preparing Stock Solutions for Metformin hydrochloride

The following data is based on the product molecular weight 165.62

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.04 mL 30.19 mL 60.38 mL
5 mM 1.21 mL 6.04 mL 12.08 mL
10 mM 0.60 mL 3.02 mL 6.04 mL
50 mM 0.12 mL 0.60 mL 1.21 mL

Calculators

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Product Documents for Metformin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Metformin hydrochloride

For research use only

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