EC 23
Tocris Bioscience, part of Bio-Techne | Catalog # 4011
Synthetic retinoid; induces differentiation of stem cells
Key Product Details
Description
Synthetic retinoid; induces differentiation of stem cells
Product Description
EC 23 is a photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.Licensing Information
Sold under license from Reinnervate Limited, patent pendingProduct Specifications
Molecular Weight
332.44
Formula
C23H24O2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid
CAS Number
104561-41-3
PubChem ID
10314719
InChI Key
OQVLOWLEEHYBJH-UHFFFAOYSA-N
SMILES
CC1(C)C2=C(C=CC(C#CC3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.24 | 100 | |
| Ethanol | 1.66 | 5 |
Preparing Stock Solutions
for EC 23
The following data is based on the product molecular weight 332.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Barnard Synthetic retinoids: structure-activity relationships. Chemistry 2009 PMID: 19821467
- Maltman Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 2009 PMID: 19381361
- Christie Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 2008 PMID: 19082150
Product Specific Notices for EC 23
For research use only
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