37 results for "Cyclin-dependent Kinase Inhibitors Small Molecules and Peptides" in Products

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Cyclin-dependent Kinase Inhibitors Small Molecules and Peptides

PD 0332991 isethionate
Catalog #: 4786
Citations (21)
Product Documents
Images (1)

Potent cdk4 and cdk6 inhibitor; brain penetrant

Alternate Names:
Palbociclib
Chemical Name:
6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt
Purity:
≥98%
Potent cdk4 and cdk6 inhibitor; brain penetrant
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4786/50
4786/10
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(R)-CR8
Catalog #: 3605
Citations (14)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue

Chemical Name:
(2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue
Catalog #
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3605/10
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AZD 5438
Catalog #: 3968
Citations (13)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Chemical Name:
4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
Catalog #
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3968/10
3968/50
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Flavopiridol hydrochloride
Catalog #: 3094
Citations (10)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk2 and cdk9

Alternate Names:
L 86-8275
Chemical Name:
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk2 and cdk9
Catalog #
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3094/10
3094/50
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Ro 3306
Catalog #: 4181
Citations (112)
Product Documents
Images (1)

Cdk1 inhibitor

Chemical Name:
5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Purity:
≥98%
Cdk1 inhibitor
Catalog #
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4181/50
4181/10
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Ryuvidine
Catalog #: 2609
Citations (3)
Product Documents
Images (1)

SETD8 inhibitor; also CDK4 inhibitor

Chemical Name:
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Purity:
≥98%
SETD8 inhibitor; also CDK4 inhibitor
Catalog #
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2609/10
2609/50
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NU 6140
Catalog #: 3301
Citations (11)
Product Documents
Images (1)

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

Chemical Name:
4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
Purity:
≥98%
Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B
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3301/10
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Senexin A
Catalog #: 4875
Citations (13)
Product Documents
Images (1)

Cdk8 inhibitor

Chemical Name:
4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Purity:
≥98%
Cdk8 inhibitor
Catalog #
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4875/10
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Roscovitine
Catalog #: 1332
Citations (47)
Product Documents
Images (1)

Cdk inhibitor

Alternate Names:
CYC 202,Seliciclib
Chemical Name:
(2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
Purity:
≥98%
Cdk inhibitor
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1332/50
1332/10
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YKL 5-124
Catalog #: 7157
Product Documents
Images (1)

Potent and selective CDK7 inhibitor; induces cell cycle arrest

Chemical Name:
N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Purity:
≥95%
Potent and selective CDK7 inhibitor; induces cell cycle arrest
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7157/5
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Kenpaullone
Catalog #: 1398
Citations (30)
Product Documents
Images (1)

GSK-3β inhibitor; also inhibits cdks

Chemical Name:
9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Purity:
≥98%
GSK-3β inhibitor; also inhibits cdks
Catalog #
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1398/10
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Purvalanol A
Catalog #: 1580
Citations (29)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Alternate Names:
NG 60
Chemical Name:
(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Catalog #
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1580/50
1580/10
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Purvalanol B
Catalog #: 1581
Citations (22)
Product Documents
Images (1)

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Alternate Names:
NG 95
Chemical Name:
(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity:
≥98%
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Catalog #
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1581/10
1581/50
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PF 3644022
Catalog #: 4279
Citations (37)
Product Documents
Images (1)

Potent MK2 inhibitor

Chemical Name:
(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
Purity:
≥98%
Potent MK2 inhibitor
Catalog #
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4279/10
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(R)-DRF053 dihydrochloride
Catalog #: 3610
Citations (4)
Product Documents
Images (1)

Potent CK1 inhibitor; also inhibits cyclin-dependent kinases

Chemical Name:
2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
Purity:
≥98%
Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
Catalog #
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3610/10
3610/50
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SNS 032
Catalog #: 4075
Citations (8)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9

Alternate Names:
BMS-387032
Chemical Name:
N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
Catalog #
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4075/10
4075/50
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CGP 60474
Catalog #: 5471
Citations (4)
Product Documents
Images (1)

Potent cdk inhibitor

Chemical Name:
3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Purity:
≥98%
Potent cdk inhibitor
Catalog #
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5471/50
5471/10
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CGP 74514 dihydrochloride
Catalog #: 5472
Product Documents
Images (1)

Potent CDK1 inhibitor

Chemical Name:
rel-N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride
Purity:
≥98%
Potent CDK1 inhibitor
Catalog #
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5472/50
5472/10
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BS 181 dihydrochloride
Catalog #: 5608
Product Documents
Images (1)

Selective cdk7 inhibitor

Chemical Name:
N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Purity:
≥98%
Selective cdk7 inhibitor
Catalog #
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5608/50
5608/10
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R 547
Catalog #: 5494
Product Documents
Images (1)

Potent and selective cdk inhibitor; orally bioavailable

Chemical Name:
[4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone
Purity:
≥98%
Potent and selective cdk inhibitor; orally bioavailable
Catalog #
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5494/10
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BMS 265246
Catalog #: 5654
Citations (1)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk1 and cdk2

Chemical Name:
(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone
Purity:
≥97%
Cdk inhibitor; potently inhibits cdk1 and cdk2
Catalog #
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5654/50
5654/10
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CVT 313
Catalog #: 6174
Citations (2)
Product Documents
Images (1)

Cdk2 and cdk5 inhibitor

Chemical Name:
2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity:
≥98%
Cdk2 and cdk5 inhibitor
Catalog #
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6174/50
6174/10
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THAL SNS 032
Catalog #: 6532
Citations (5)
Product Documents
Images (2)

Potent and selective Cdk9 Degrader (PROTAC®)

Chemical Name:
N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide
Purity:
≥98%
Application of THAL SNS 032 in MOLT-4 cells
(2)
Catalog #
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6532/5
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NVP 2
Catalog #: 6535
Citations (14)
Product Documents
Images (1)

Potent and selective ATP-competitive CDK9 inhibitor

Chemical Name:
4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
Purity:
≥97%
Potent and selective ATP-competitive CDK9 inhibitor
Catalog #
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6535/5
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K 03861
Catalog #: 6789
Product Documents
Images (1)

Potent CDK2 inhibitor

Alternate Names:
AUZ 454
Chemical Name:
N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
Purity:
≥98%
Potent CDK2 inhibitor
Catalog #
Availability
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6789/10
6789/50
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