AZD 5438

Name: AZD 5438
Brand: Tocris Bioscience
SKU: 3968

Tocris Bioscience, part of Bio-Techne | Catalog # 3968

Citations (17)

COA / SDS

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
Chemical Name:	4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	371.46

View Full Technical Details for AZD 5438

Technical Data
Citations

Biological Activity for AZD 5438

AZD 5438 is a potent inhibitor of cyclin dependent kinases (cdks; reported IC₅₀ values are 6 - 45, 14, 16 and 20 nM for cdk2, cdk5, cdk1 and cdk9 respectively). Also inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZD 5438

AZD 5438 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 5438

M. Wt	371.46
Formula	C₁₈H₂₁N₅O₂S
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	602306-29-6
PubChem ID	16747683
InChi Key	WJRRGYBTGDJBFX-UHFFFAOYSA-N
Smiles	CS(C(C=C3)=CC=C3NC1=NC(C2=CN=C(C)N2C(C)C)=CC=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 5438

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.15	100

Preparing Stock Solutions for AZD 5438

The following data is based on the product molecular weight 371.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for AZD 5438

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Byth AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol.Cancer Ther. 2009 PMID: 19509270