K 03861

Name: K 03861
Brand: Tocris Bioscience
SKU: 6789

Tocris Bioscience, part of Bio-Techne | Catalog # 6789

COA / SDS

Potent CDK2 inhibitor

Key Product Details

Description:	Potent CDK2 inhibitor
Alternative Names:	AUZ 454
Chemical Name:	N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	501.51

View Full Technical Details for K 03861

Technical Data
Citations

Biological Activity for K 03861

K 03861 is a potent Cdk2 inhibitor (K_d values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.

Compound Libraries for K 03861

K 03861 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for K 03861

M. Wt	501.51
Formula	C₂₄H₂₆F₃N₇O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	853299-07-7
InChi Key	PWDLXPJQFNVTNL-UHFFFAOYSA-N
Smiles	CN1CCN(CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2)C(F)(F)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for K 03861

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.08	50
	ethanol	50.15	100

Preparing Stock Solutions for K 03861

The following data is based on the product molecular weight 501.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for K 03861

References are publications that support the biological activity of the product.

Alexander Type II inhibitors targeting Cdk2 ACS.Chem.Biol 2015 PMID: 26158339
Song NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 2017 PMID: 29033307