Flavopiridol hydrochloride

Name: Flavopiridol hydrochloride
Brand: Tocris Bioscience
SKU: 3094

Tocris Bioscience, part of Bio-Techne | Catalog # 3094

Citations (14)

COA / SDS

Cdk inhibitor; potently inhibits cdk2 and cdk9

Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk2 and cdk9
Alternative Names:	L 86-8275
Chemical Name:	2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	438.3

View Full Technical Details for Flavopiridol hydrochloride

Technical Data
Citations

Biological Activity for Flavopiridol hydrochloride

Flavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC₅₀ = 25 - 160 nM) in vitro.

Compound Libraries for Flavopiridol hydrochloride

Flavopiridol hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Flavopiridol hydrochloride

M. Wt	438.3
Formula	C₂₁H₂₀ClNO₅.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	131740-09-5
PubChem ID	9910986
InChi Key	LGMSNQNWOCSPIK-LWHGMNCYSA-N
Smiles	CN(CC3)C[C@@H](O)[C@H]3[C@]1=C(OC(C4=CC=CC=C4Cl)=CC2=O)C2=C(O)C=C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flavopiridol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.83	100
	DMSO	43.83	100

Preparing Stock Solutions for Flavopiridol hydrochloride

The following data is based on the product molecular weight 438.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.41 mL	22.82 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Flavopiridol hydrochloride

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Ambrosini The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 2008 PMID: 18381438
Losiewicz Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm.
Kaur Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 1992 PMID: 1279187