(R)-DRF053 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3610
Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
Key Product Details
Description
Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
Product Description
(R)-DRF053 dihydrochloride is a potent casein kinase 1 (CK1) inhibitor (IC50 = 14 nM). Also an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (IC50 values are 0.093 - 0.29, 0.21 and 0.82 μM for cdk2, cdk5 and cdk7, respectively). Shown to inhibit amyloid-β production in N2A-APP695 cells.Product Specifications
Molecular Weight
490.43
Formula
C23H27N7O.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
CAS Number
1241675-76-2
PubChem ID
71433624
InChI Key
BQPRBNGSDBTKAK-ZEECNFPPSA-N
SMILES
CC(C)N2C1=NC(N[C@H](CC)CO)=NC(NC3=CC(C4=NC=CC=C4)=CC=C3)=C1N=C2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 49.04 | 100 | |
| DMSO | 49.04 | 100 |
Preparing Stock Solutions
for (R)-DRF053 dihydrochloride
The following data is based on the product molecular weight 490.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.20 mL | 20.39 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
- Oumata Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem.
Product Specific Notices for (R)-DRF053 dihydrochloride
For research use only
Loading...
Loading...