Senexin A

Name: Senexin A
Brand: Tocris Bioscience
SKU: 4875

Tocris Bioscience, part of Bio-Techne | Catalog # 4875

Citations (17)

COA / SDS

Cdk8 inhibitor

Key Product Details

Description:	Cdk8 inhibitor
Chemical Name:	4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	310.78

View Full Technical Details for Senexin A

Technical Data
Citations

Biological Activity for Senexin A

Senexin A is a cyclin-dependent kinase 8 (cdk8) inhibitor (IC₅₀ = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.

Licensing Information

Sold under license from Senex Biotechnology.

Technical Data for Senexin A

M. Wt	310.78
Formula	C₁₇H₁₄N₄.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1780390-76-2
PubChem ID	90488980
InChi Key	POENYXHGUHRXFR-UHFFFAOYSA-N
Smiles	N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Senexin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.08	100

Preparing Stock Solutions for Senexin A

The following data is based on the product molecular weight 310.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.09 mL	32.18 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for Senexin A

References are publications that support the biological activity of the product.

Porter Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 22869755